Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community
Identifieur interne : 002212 ( Main/Exploration ); précédent : 002211; suivant : 002213Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community
Auteurs : Prachi Mehta [Australie] ; George D. Mellick [Australie] ; Dominic B. Rowe [Australie] ; Glenda M. Halliday [Australie] ; Michael M. Jones [Australie] ; Neil Manwaring [Australie] ; Himesha Vandebona [Australie] ; Peter A. Silburn [Australie] ; Jie Jin Wang [Australie] ; Paul Mitchell [Australie] ; Carolyn M. Sue [Australie]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-01-30.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Australie.
English descriptors
- KwdEn :
- Age of Onset, Aged, Aged, 80 and over, Australia (epidemiology), Case-Control Studies, DNA, Mitochondrial (classification), DNA, Mitochondrial (genetics), Europe (ethnology), European Continental Ancestry Group (genetics), Female, Genetic Predisposition to Disease, Haplotypes (genetics), Humans, Male, Middle Aged, Mitochondrial DNA, Nervous system diseases, Parkinson Disease (epidemiology), Parkinson Disease (ethnology), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Polymorphism, Single Nucleotide, Prevalence, Prevention, Risk, mitochondrial DNA haplogroups, prevalence.
- MESH :
- chemical , classification : DNA, Mitochondrial.
- geographic , epidemiology : Australia.
- geographic , ethnology : Europe.
- chemical , genetics : DNA, Mitochondrial.
- epidemiology : Parkinson Disease.
- ethnology : Parkinson Disease.
- genetics : European Continental Ancestry Group, Haplotypes, Parkinson Disease.
- Age of Onset, Aged, Aged, 80 and over, Case-Control Studies, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk.
Abstract
MtDNA haplogroups J and K have been associated with a decreased risk of developing Parkinson's disease (PD). To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population‐based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/RFLP techniques. Of the 890 subjects with PD, 10.6% were haplogroup J (95% CI 8.6–12.8, n = 94) and 7.1% were haplogroup K (95% CI 5.5–8.9, n = 63). In our controls, 10.2% belonged to haplogroup J (95% CI 9.2–11.2, n = 356), and 7.8% were in haplogroup K (95% CI 6.9–8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population‐based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22389
Affiliations:
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To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population‐based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/RFLP techniques. Of the 890 subjects with PD, 10.6% were haplogroup J (95% CI 8.6–12.8, n = 94) and 7.1% were haplogroup K (95% CI 5.5–8.9, n = 63). In our controls, 10.2% belonged to haplogroup J (95% CI 9.2–11.2, n = 356), and 7.8% were in haplogroup K (95% CI 6.9–8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population‐based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Australie</li></country><settlement><li>Sydney</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Mehta, Prachi" sort="Mehta, Prachi" uniqKey="Mehta P" first="Prachi" last="Mehta">Prachi Mehta</name></noRegion><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><name sortKey="Jones, Michael M" sort="Jones, Michael M" uniqKey="Jones M" first="Michael M." last="Jones">Michael M. Jones</name><name sortKey="Manwaring, Neil" sort="Manwaring, Neil" uniqKey="Manwaring N" first="Neil" last="Manwaring">Neil Manwaring</name><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><name sortKey="Rowe, Dominic B" sort="Rowe, Dominic B" uniqKey="Rowe D" first="Dominic B." last="Rowe">Dominic B. Rowe</name><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><name sortKey="Sue, Carolyn M" sort="Sue, Carolyn M" uniqKey="Sue C" first="Carolyn M." last="Sue">Carolyn M. Sue</name><name sortKey="Vandebona, Himesha" sort="Vandebona, Himesha" uniqKey="Vandebona H" first="Himesha" last="Vandebona">Himesha Vandebona</name><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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